John Maunsell, PhD
Albert D. Lasker Professor of Neurobiology
Director, Grossman Institute
for Neuroscience, Quantitative Biology and Human Behavior
BS Zoology, Duke University
PhD Biology, California Institute of Technology
Jackson Cone, PhD
BA Molecular & Cell Biology, UC Berkeley
PhD Neuroscience, University of Illinois
I joined the Maunsell lab in 2015 after completing my graduate work in the laboratory of Dr. Mitchell Roitman at the University of Illinois, Chicago. My work focused on questions related to neuronal readout. How does the brain decode information from neuronal activity in visual cerebral cortex? Are particular spiking patterns, epochs, or brain areas preferentially decoded from during visual specific decisions? To address these questions, I use range of optogenetic and neurophysiological approaches in mice trained to work at perceptual threshold. When not in lab, I spend far too much time restoring a 140 year old home with my wife.
BS Neuroscience and BA English Writing and Philosophy, University of Pittsburgh
My research focuses on the dynamics of signal decoding in the primary visual cortex of mice. Using optogenetic activation of inhibitory interneurons in V1, I measure changes in behavioral performance with high temporal precision to define when and how neuronal activity in V1 is used to perform a visually-guided task. These measurements of V1 readout can then be used to build more accurate decoding models of sensory cortex.
B.A. Psychology, University of Illinois at Chicago
Supriya Ghosh, PhD
NARSAD Young Investigator
BS, Physics University of Calcutta
MS Physics, Devi Ahilya University
PhD Neuroscience, National Centre for Biological Sciences, TIRF Bangalore
My research is focused on understanding the neurophysiological mechanisms underlying fundamental components of attention– selective attention and attentional effort (intensive aspect of attention). I isolate selective attention and effort using a novel experimental approach that precisely and independently controls the distinct components of attentional performance: sensitivity (d’), perceptual criterion, and motor criterion in a visual spatial attention task, while simultaneously monitoring spiking in visual area V4 and the superior colliculus (SC) in monkeys. In another project I am investigating the role of norepinephrine (NE) neuromodulation on attentional effort by pharmacological inactivation of NE release within the SC. I am also testing whether behavioral performance can be improved by a more temporally specific NE activation during the period of attended stimuli presentation within a single trial. By selectively expression of photosensitive excitatory opsins (ChR2) in the locus coeruleus norepinephrine (LC-NE) of monkeys I can elucidate the role of NE neuromodulation on visual attention.
BS Molecular, Cellular and Developmental Biology, Yale University
I am an MSTP student doing my thesis work in the Maunsell and MacLean labs. Using electrophysiology and two-photon imaging in awake mice, I am studying the dynamics, correlation changes, and network dynamics of divisive normalization, a canonical nonlinear computation. Normalization is involved in multisensory processing, and has also been shown to underlie pairwise correlations changes in attention (Verhoef and Maunsell, 2017). Over the course of my career as a physician-scientist, I plan to continue studying central brain computations that, when aberrant, may factor in neurological and psychiatric disorders. Outside the lab, I enjoy rock climbing, painting, reading, and spending time with family and friends.
Research Specialist and Lab Manager
B.A. in Biochemistry and Molecular Biology, Gustavus Adolphus College